Challenge: Power and Sample Size
Question Number 1

If the sample size for a trial was calculated based on the following assumptions:

  • Response rate Group A = 65%
  • Response rate Group B = 50%
  • Significance level 5%
  • Power = 90%
  • Objective to show a difference between treatment groups


Which of the following changes to the assumptions would result in the required sample size increasing?

1) Changing the Expected Response Rate in Group A to 68% while all other assumptions remain the same

2) Changing the Expected Response Rate in Group B to 48% while all other assumptions remain the same

3) Changing the Power Level to 80% while all other assumptions remain the same

Which of the following is correct

A
1 only
B
2 only
C
3 only
D
None of them

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